Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus

Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus

The micronutrients vitamins B9 and B12 act as methyl donors in the one-carbon metabolism involved in transmethylation reactions which critically influence epigenetic mechanisms and gene expression. Both vitamins are essential for proper development, and their deficiency during pregnancy has been ass...

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Bibliographic Details
Main Authors: Lynda Saber Cherif, Grégory Pourié, Andréa Geoffroy, Amélia Julien, Déborah Helle, Aurélie Robert, Rémy Umoret, Jean-Louis Guéant, Carine Bossenmeyer-Pourié, Jean-Luc Daval
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
development
growth
hypothalamus
energy homeostasis
orexigenic and anorexigenic pathways
gestational deficiency
folate
vitamin b12
folate supplementation
Online Access:https://www.mdpi.com/1422-0067/20/20/5097

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https://www.mdpi.com/1422-0067/20/20/5097

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