Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining

Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining

Detection of antigen specificity in a blood sample is limited by low frequencies of individual clones. Here the authors develop an MHC class II combinatorial technique and apply it to immunophenotype human CD4+ T cells of multiple specificities in response to influenza vaccine in single blood sample...

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Bibliographic Details
Main Authors: Hannes Uchtenhagen, Cliff Rims, Gabriele Blahnik, I-Ting Chow, William W. Kwok, Jane H. Buckner, Eddie A. James
Format: Article
Language:English
Published: Nature Publishing Group 2016-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12614

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https://doi.org/10.1038/ncomms12614

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