Non-Canonical WNT5A Signaling Through RYK Contributes to Aggressive Phenotype of the Rheumatoid Fibroblast-Like Synoviocytes

Non-Canonical WNT5A Signaling Through RYK Contributes to Aggressive Phenotype of the Rheumatoid Fibroblast-Like Synoviocytes

We hypothesized that WNT5A could contribute to the enhanced migration and invasiveness of rheumatoid arthritis fibroblast-like synoviocytes (RA FLS), which is one of the incompletely understood aspects of the RA FLS aggressive phenotype. This hypothesis is based on the previous evidence of a WNT5A r...

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Bibliographic Details
Main Authors: Angela Rodriguez-Trillo, Nerea Mosquera, Carmen Pena, Fatima Rivas-Tobío, Antonio Mera-Varela, Antonio Gonzalez, Carmen Conde
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
fibroblast-like synoviocytes
migration
invasion
inflammatory response
WNT5A
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.555245/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.555245/full

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