An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

The Asian lineage of Zika virus (ZIKV) has acquired a mutation in NS1 that enhances mosquito infection. Here, Xia et al. show that the same mutation interferes with interferon production through interaction with TBK1 and affects ZIKV replication in mice.

Bibliographic Details
Main Authors: Hongjie Xia, Huanle Luo, Chao Shan, Antonio E. Muruato, Bruno T. D. Nunes, Daniele B. A. Medeiros, Jing Zou, Xuping Xie, Maria Isabel Giraldo, Pedro F. C. Vasconcelos, Scott C. Weaver, Tian Wang, Ricardo Rajsbaum, Pei-Yong Shi
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02816-2

Internet

https://doi.org/10.1038/s41467-017-02816-2

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