Structural insights into SorCS2–Nerve Growth Factor complex formation
The Sortilin-related CNS-expressed receptor 2 (SorCS2)–proneurotrophin signaling system regulates neuronal plasticity and its dysfunction is linked to schizophrenia. Here the authors present the structures of the SorCS2 ectodomain alone and in complex with Nerve Growth Factor, which provides insight...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05405-z |