Nrf2 epigenetic derepression induced by running exercise protects against osteoporosis

Abstract Osteoporosis (OP) is a common skeletal disease involving low bone mineral density (BMD) that often leads to fragility fracture, and its development is affected by multiple cellular pathologies and associated with marked epigenetic alterations of osteogenic genes. Proper physical exercise is...

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Bibliographic Details
Main Authors: Xingren Chen, Xiaobo Zhu, Ai Wei, Fang Chen, Qi Gao, Ke Lu, Qing Jiang, Wangsen Cao
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-020-00128-8