A Four-Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotypes C and D

A Four-Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotypes C and D

Human botulism can be caused by botulinum neurotoxin (BoNT) serotypes A to G. Here, we present an antibody-based antitoxin composed of four human monoclonal antibodies (mAbs) against BoNT/C, BoNT/D, and their mosaic toxins. This work built on our success in generating protective mAbs to BoNT /A, B a...

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Bibliographic Details
Main Authors: Consuelo Garcia-Rodriguez, Shude Yan, Isin N. Geren, Kristeene A. Knopp, Jianbo Dong, Zhengda Sun, Jianlong Lou, Fraser Conrad, Wei-Hua Wen, Shauna Farr-Jones, Theresa J. Smith, Jennifer L. Brown, Janet C. Skerry, Leonard A. Smith, James D. Marks
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Toxins
Subjects:
botulinum neurotoxin
oligoclonal antibodies
serotype C botulism
serotype D botulism
recombinant antibodies
antibody engineering
Online Access:https://www.mdpi.com/2072-6651/13/9/641

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https://www.mdpi.com/2072-6651/13/9/641

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