Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation

• Main Authors: Shruti V. Kabadi, Alan I. Faden
• Format: Article
• Language: English
• Published: MDPI AG 2014-01-01
• Series: International Journal of Molecular Sciences
• Subjects: experimental head injury; clinical trial design; translational challenges; multipotential neuroprotective approaches; programmed cell death; caspase-dependent and AIF-mediated cell death; microglial and astrocyte activation; autophagy
• Online Access: http://www.mdpi.com/1422-0067/15/1/1216

Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating such secondary injury has provided the conceptual basis for neuroprotective treatments. Despite strong experimental data, more than 30 clinical trials of neuroprotection in TBI patients have failed. In part, these failures likely reflect methodological differences between the clinical and animal studies, as well as inadequate pre-clinical evaluation and/or trial design problems. However, recent changes in experimental approach and advances in clinical trial methodology have raised the potential for successful clinical translation. Here we critically analyze the current limitations and translational opportunities for developing successful neuroprotective therapies for TBI.