Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation

Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation

Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating such secondary injury has provided the conceptual basis for neuroprotective treatments. Despite strong experimental data, m...

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Bibliographic Details
Main Authors: Shruti V. Kabadi, Alan I. Faden
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:International Journal of Molecular Sciences
Subjects:
experimental head injury
clinical trial design
translational challenges
multipotential neuroprotective approaches
programmed cell death
caspase-dependent and AIF-mediated cell death
microglial and astrocyte activation
autophagy
Online Access:http://www.mdpi.com/1422-0067/15/1/1216

Internet

http://www.mdpi.com/1422-0067/15/1/1216

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