Generation of a α-synuclein-based rat model of Parkinson's disease

Generation of a α-synuclein-based rat model of Parkinson's disease

Two missense mutations (A30P and A53T) in the gene for alpha-synuclein (α-syn) cause familial Parkinson's disease (PD) in a small cohort. There is increasing evidence to propose that abnormal metabolism and accumulation of α-syn in dopaminergic neurons play a role in the development of familial...

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Bibliographic Details
Main Authors: Alessandra Recchia, David Rota, Patrizia Debetto, Daniele Peroni, Diego Guidolin, Alessandro Negro, Stephen D. Skaper, Pietro Giusti
Format: Article
Language:English
Published: Elsevier 2008-04-01
Series:Neurobiology of Disease
Subjects:
α-Synuclein
Parkinson's disease
Neurodegeneration
Animal models
Fusion protein
Dopaminergic loss
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107002483

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http://www.sciencedirect.com/science/article/pii/S0969996107002483

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