Potentiation of immunomodulatory antibody therapy with oncolytic viruses for treatment of cancer

Identification of the immune suppressive mechanisms active within the tumor microenvironment led to development of immunotherapeutic strategies aiming to reverse the immunosuppression and to enhance the function of tumor-infiltrating lymphocytes. Of those, cancer therapy with antibodies targeting th...

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Bibliographic Details
Main Authors: Dmitriy Zamarin, Jedd D Wolchok
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770516300262