Sphingosine-1-Phosphate Catabolizing Enzymes Predict Better Prognosis in Triple-Negative Breast Cancer Patients and Correlates With Tumor-Infiltrating Immune Cells

Sphingosine-1-Phosphate Catabolizing Enzymes Predict Better Prognosis in Triple-Negative Breast Cancer Patients and Correlates With Tumor-Infiltrating Immune Cells

Background: Triple-negative breast cancer (TNBC) is associated with a poor prognosis. Sphingosine-1-phosphate (S1P), a potent sphingolipid metabolite, has been implicated in many processes that are important for breast cancer (BC). S1P signaling regulates tumorigenesis, and response to chemotherapy...

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Bibliographic Details
Main Authors: Rajeev Nema, Ashok Kumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
breast cancer
sphingosine-1-phosphate
SGPP1
PLPP3
S1PR4
tumor-infiltrating immune cells
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.697922/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.697922/full

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