Evolving Concepts of Reflux: The Ups and Downs of the LES

Evolving Concepts of Reflux: The Ups and Downs of the LES

The common denominator for virtually all episodes of gastroesophageal reflux in health and disease is the loss of the barrier that confines the gastric environment to the stomach. Factors important in the function of the barrier are its pressure, length and position. In early reflux disease, overeat...

Full description

Bibliographic Details
Main Author: Tom R DeMeester
Format: Article
Language:English
Published: Hindawi Limited 2002-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2002/652650
id doaj-a1ff2da46cef4cb69e46ff9a6b7a8e41
record_format Article
spelling doaj-a1ff2da46cef4cb69e46ff9a6b7a8e412020-11-24T22:28:21ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79002002-01-0116532733110.1155/2002/652650Evolving Concepts of Reflux: The Ups and Downs of the LESTom R DeMeester0Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USAThe common denominator for virtually all episodes of gastroesophageal reflux in health and disease is the loss of the barrier that confines the gastric environment to the stomach. Factors important in the function of the barrier are its pressure, length and position. In early reflux disease, overeating, gastric distention, delayed emptying and aerophagia lead to transient losses of the barrier. A permanent loss results from inflammatory injury to the muscle of the barrier with free flow of gastric juice into the esophageal body and its subsequent injury. Corrective therapy requires augmentation or restoration of barrier function.http://dx.doi.org/10.1155/2002/652650
collection DOAJ
language English
format Article
sources DOAJ
author Tom R DeMeester
spellingShingle Tom R DeMeester
Evolving Concepts of Reflux: The Ups and Downs of the LES
Canadian Journal of Gastroenterology
author_facet Tom R DeMeester
author_sort Tom R DeMeester
title Evolving Concepts of Reflux: The Ups and Downs of the LES
title_short Evolving Concepts of Reflux: The Ups and Downs of the LES
title_full Evolving Concepts of Reflux: The Ups and Downs of the LES
title_fullStr Evolving Concepts of Reflux: The Ups and Downs of the LES
title_full_unstemmed Evolving Concepts of Reflux: The Ups and Downs of the LES
title_sort evolving concepts of reflux: the ups and downs of the les
publisher Hindawi Limited
series Canadian Journal of Gastroenterology
issn 0835-7900
publishDate 2002-01-01
description The common denominator for virtually all episodes of gastroesophageal reflux in health and disease is the loss of the barrier that confines the gastric environment to the stomach. Factors important in the function of the barrier are its pressure, length and position. In early reflux disease, overeating, gastric distention, delayed emptying and aerophagia lead to transient losses of the barrier. A permanent loss results from inflammatory injury to the muscle of the barrier with free flow of gastric juice into the esophageal body and its subsequent injury. Corrective therapy requires augmentation or restoration of barrier function.
url http://dx.doi.org/10.1155/2002/652650
work_keys_str_mv AT tomrdemeester evolvingconceptsofrefluxtheupsanddownsoftheles
_version_ 1725746526269997056

Similar Items