Antigen-delivery through invariant chain (CD74) boosts CD8 and CD4 T cell immunity

Antigen-delivery through invariant chain (CD74) boosts CD8 and CD4 T cell immunity

Eradication of tumors by the immune system relies on the efficient activation of a T-cell response. For many years, the main focus of cancer immunotherapy has been on cytotoxic CD8 T-cell. However, stimulation of CD4 helper T cells is critical for the promotion and maintenance of immune memory, thus...

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Bibliographic Details
Main Authors: Nadia Mensali, Amalie Grenov, Niladri Bhusan Pati, Pierre Dillard, Marit Renée Myhre, Gustav Gaudernack, Gunnar Kvalheim, Else Marit Inderberg, Oddmund Bakke, Sébastien Wälchli
Format: Article
Language:English
Published: Taylor & Francis Group 2019-03-01
Series:OncoImmunology
Subjects:
vaccines
invariant chain
dendritic cells
t cells
tcr
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1558663

Internet

http://dx.doi.org/10.1080/2162402X.2018.1558663

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