The Role of Janus Kinase 3 in the Regulation of Na+/K+ ATPase under Energy Depletion

The Role of Janus Kinase 3 in the Regulation of Na+/K+ ATPase under Energy Depletion

Background/Aims: Janus kinase-3 (JAK3) is activated during energy depletion. Energy-consuming pumps include the Na+/K+-ATPase. The present study explored whether JAK3 regulates Na+/K+-ATPase in dendritic cells (DCs). Methods: Ouabain (100 µM)-sensitive (Iouabain) and K+-induced (Ipump) outward curre...

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Bibliographic Details
Main Authors: Zohreh Hosseinzadeh, Sabina Honisch, Evi Schmid, Kashif Jilani, Kalina Szteyn, Shefalee Bhavsar, Yogesh Singh, Monica Palmada, Anja T. Umbach, Ekaterina Shumilina, Florian Lang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
K+-current
Ouabain
DNP
ATP
Online Access:http://www.karger.com/Article/FullText/430133

Internet

http://www.karger.com/Article/FullText/430133

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