Altered Activity of SK Channel Underpins Morphine Withdrawal Relevant Psychiatric Deficiency in Infralimbic to Accumbens Shell Pathway

Altered Activity of SK Channel Underpins Morphine Withdrawal Relevant Psychiatric Deficiency in Infralimbic to Accumbens Shell Pathway

Drug addiction can be viewed as a chronic psychiatric disorder that is related to dysfunction of neural circuits, including reward deficits, stress surfeits, craving changes, and compromised executive function. The nucleus accumbens (NAc) plays a crucial role in regulating craving and relapse, while...

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Bibliographic Details
Main Authors: Liang Qu, Yuan Wang, Shun-Nan Ge, Nan Li, Jian Fu, Yue Zhang, Xin Wang, Jiang-Peng Jing, Yang Li, Qiang Wang, Guo-Dong Gao, Shi-Ming He, Xue-Lian Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Psychiatry
Subjects:
morphine
conditioned place preference
nucleus accumbens
medium spiny neurons
medial prefrontal cortex
small conductance calcium-activated potassium channels (SK channels)
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2019.00240/full

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https://www.frontiersin.org/article/10.3389/fpsyt.2019.00240/full

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