Phenotypic and Multi-Omics Characterization of Escherichia coli K-12 Adapted to Chlorhexidine Identifies the Role of MlaA and Other Cell Envelope Alterations Regulated by Stress Inducible Pathways in CHX Resistance

Phenotypic and Multi-Omics Characterization of Escherichia coli K-12 Adapted to Chlorhexidine Identifies the Role of MlaA and Other Cell Envelope Alterations Regulated by Stress Inducible Pathways in CHX Resistance

Chlorhexidine (CHX) is an essential medicine used as a topical antiseptic in skin and oral healthcare treatments. The widespread use of CHX has increased concerns regarding the development of antiseptic resistance in Enterobacteria and its potential impact on cross-resistance to other antimicrobials...

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Bibliographic Details
Main Authors: Branden S. J. Gregorchuk, Shelby L. Reimer, Kari A. C. Green, Nicola H. Cartwright, Daniel R. Beniac, Shannon L. Hiebert, Timothy F. Booth, Patrick M. Chong, Garrett R. Westmacott, George G. Zhanel, Denice C. Bay
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
chlorhexidine
retrograde phospholipid transport
disinfectant
Escherichia coli
MlaA
antiseptic resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.659058/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.659058/full

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