Copper-Catalyzed Synthesis, Bio-Evaluation, and in Silico Studies of 2-Aryl-N-alkylbenzimidazoles as Neuroprotective Agents

Copper-Catalyzed Synthesis, Bio-Evaluation, and in Silico Studies of 2-Aryl-N-alkylbenzimidazoles as Neuroprotective Agents

2-aryl-N-alkylbenzimidazole derivatives synthesized by CuI/PPh3 promoted direct coupling of N-alkylbenzimidazoles with aryl bromides. In vitro neurotoxicities of 20 compounds were evaluated, and the neuroprotective abilities of low-neurotoxic compounds (3b, 3g, 3h, 3i, 3j, 3k, 3o, 3q, 3s and 3t) wer...

Full description

Bibliographic Details
Main Authors: Yun-Xin Yao, Nan-Nan Jia, Ya-Nan Cao, Xing-Xiu Chen, Feng Gao, Xiao-Xia Liang
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Catalysts
Subjects:
2-arylbenzimidazoles
arylation
copper-catalysis
neuroprotective effect
molecular docking
Online Access:http://www.mdpi.com/2073-4344/8/10/433

Internet

http://www.mdpi.com/2073-4344/8/10/433

Similar Items