Synaptic signaling and aberrant RNA splicing in autism spectrum disorders

Synaptic signaling and aberrant RNA splicing in autism spectrum disorders

Interactions between presynaptic and postsynaptic cellular adhesion molecules drive synapse maturation during development. These trans-synaptic interactions are regulated by alternative splicing of cellular adhesion molecule RNAs, which ultimately determines neurotransmitter phenotype. The diverse...

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Bibliographic Details
Main Authors: Ryan M Smith, Wolfgang eSadee
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-01-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Gene Expression
Autism Spectrum Disorder
neural development
neurexin
neuroligin
synaptogenesis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsyn.2011.00001/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnsyn.2011.00001/full

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