LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy

LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy

Abstract Genetically engineered pigs are a promising source for islet cell transplantation in type 1 diabetes, but the strong human anti-pig immune response prevents its successful clinical application. Here we studied the efficacy of neonatal porcine islet-like cell clusters (NPICCs) overexpressing...

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Bibliographic Details
Main Authors: L. Wolf-van Buerck, M. Schuster, F. S. Oduncu, A. Baehr, T. Mayr, S. Guethoff, J. Abicht, B. Reichart, N. Klymiuk, E. Wolf, J. Seissler
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03913-4

Internet

https://doi.org/10.1038/s41598-017-03913-4

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