Probiotic sonicates selectively induce mucosal immune cells apoptosis through ceramide generation via neutral sphingomyelinase.

Probiotic sonicates selectively induce mucosal immune cells apoptosis through ceramide generation via neutral sphingomyelinase.

Probiotics appear to be beneficial in inflammatory bowel disease, but their mechanism of action is incompletely understood. We investigated whether probiotic-derived sphingomyelinase mediates this beneficial effect.Neutral sphingomyelinase (NSMase) activity was measured in sonicates of the probiotic...

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Bibliographic Details
Main Authors: Sandra Angulo, Albert Morales, Silvio Danese, Laura Llacuna, Maria Carme Masamunt, Nicole Pultz, Maria Grazia Cifone, Claudio De Simone, Salvadora Delgado, Jordi Vila, Julián Panés, Curtis Donskey, Jose C Fernández-Checa, Claudio Fiocchi, Miquel Sans
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3052310?pdf=render

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http://europepmc.org/articles/PMC3052310?pdf=render

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