Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation

Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation

Summary: The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that controls cell cycle transitions. Its regulation by the spindle assembly checkpoint (SAC) is coordinated with the attachment of sister chromatids to the mitotic spindle. APC/C SUMOylation on APC4 ensures timely a...

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Bibliographic Details
Main Authors: Stanislau Yatskevich, Jessie S. Kroonen, Claudio Alfieri, Thomas Tischer, Anna C. Howes, Linda Clijsters, Jing Yang, Ziguo Zhang, Kaige Yan, Alfred C.O. Vertegaal, David Barford
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
APC/C
SUMOylation
SAC
MCC
WHB domain
ubiquitination
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002436

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721002436

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