Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1.

Replication forks are vulnerable to wayward nuclease activities. We report here our discovery of a new member in guarding genome stability at replication forks. We previously isolated a Drosophila mutation, wuho (wh, no progeny), characterized by a severe fertility defect and affecting expression of...

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Bibliographic Details
Main Authors: I-Cheng Cheng, Betty Chamay Chen, Hung-Hsun Shuai, Fan-Ching Chien, Peilin Chen, Tao-shih Hsieh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4709127?pdf=render