Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons

Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons

Neurons face unique challenges of transporting nascent autophagic vacuoles (AVs) from distal axons toward the soma, where mature lysosomes are mainly located. Autophagy defects have been linked to Alzheimer’s disease (AD). However, the mechanisms underlying altered autophagy remain unknown. Here, we...

Full description

Bibliographic Details
Main Authors: Prasad Tammineni, Xuan Ye, Tuancheng Feng, Daniyal Aikal, Qian Cai
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
alzheimer's
Snapin
dynein motor
autophagic stress
retrograde transport
amphisome
Online Access:https://elifesciences.org/articles/21776

Internet

https://elifesciences.org/articles/21776

Similar Items