Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells

Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells

Abstract Multidrug resistance (MDR) triggered by ATP binding cassette (ABC) transporter such as ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no commercial available MDR modulator approved by FDA was used in clinic. Tyrosine kinase inhibitors (TKIs) have been administrat...

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Bibliographic Details
Main Authors: Shaocong Wu, Liwu Fu
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Cancer
Subjects:
Tyrosine kinase inhibitor
ABC transporter
Multiple drug resistance
Chemotherapy
Chemosensitizer
Online Access:http://link.springer.com/article/10.1186/s12943-018-0775-3

Internet

http://link.springer.com/article/10.1186/s12943-018-0775-3

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