FGF, Insulin, and SMAD Signaling Cooperate for Avian Primordial Germ Cell Self-Renewal

Precise self-renewal of the germ cell lineage is fundamental to fertility and reproductive success. The early precursors for the germ lineage, primordial germ cells (PGCs), survive and proliferate in several embryonic locations during their migration to the embryonic gonad. By elucidating the active...

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Bibliographic Details
Main Authors: Jemima Whyte, James D. Glover, Mark Woodcock, Joanna Brzeszczynska, Lorna Taylor, Adrian Sherman, Pete Kaiser, Michael J. McGrew
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115003057