Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells

Summary: Climbing fibers (CFs) provide instructive signals driving cerebellar learning, but mechanisms causing the variable CF responses in Purkinje cells (PCs) are not fully understood. Using a new experimentally validated PC model, we unveil the ionic mechanisms underlying CF-evoked distinct spike...

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Bibliographic Details
Main Authors: Yunliang Zang, Stéphane Dieudonné, Erik De Schutter
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471831088X