Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease

<p>Abstract</p> <p>The excitotoxin quinolinic acid (QUIN) is synthesized through the kynurenine pathway (KP) by activated monocyte lineage cells. QUIN is likely to play a role in the pathogenesis of several major neuroinflammatory diseases including Alzheimer's disease (AD). T...

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Bibliographic Details
Main Authors: Brew Bruce J, Ting Ka, Guillemin Gilles J
Format: Article
Language:English
Published: BMC 2009-12-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/6/1/36