Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities

Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities

Introduction: Group 2 pulmonary hypertension (PH), defined as a mean pulmonary arterial pressure ≥25 mmHg with elevated pulmonary capillary wedge pressure >15 mmHg, has no approved therapy and patients often die from right ventricular failure (RVF). Alterations in mitochondrial metabolism, no...

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Bibliographic Details
Main Authors: Ping Yu Xiong, Lian Tian, Kimberly J. Dunham-Snary, Kuang-Hueih Chen, Jeffrey D. Mewburn, Monica Neuber-Hess, Ashley Martin, Asish Dasgupta, Francois Potus, Stephen L. Archer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
aortic stenosis
PKM2 pyruvate kinase M2
mitochondrial fission
MiD51
supra-coronary aortic banding (SAB)
group 2 PH
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2018.00195/full

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https://www.frontiersin.org/article/10.3389/fcvm.2018.00195/full

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