Development and Validation of a Mathematical Model to Predict the Complexity of FMR1 Allele Combinations

Development and Validation of a Mathematical Model to Predict the Complexity of FMR1 Allele Combinations

The polymorphic trinucleotide repetitive region in the FMR1 gene 5′UTR contains AGG interspersions, particularly in normal-sized alleles (CGG < 45). In this range repetitive stretches are typically interrupted once or twice, although alleles without or with three or more AGG interspersions ca...

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Bibliographic Details
Main Authors: Bárbara Rodrigues, Emídio Vale-Fernandes, Nuno Maia, Flávia Santos, Isabel Marques, Rosário Santos, António J. A. Nogueira, Paula Jorge
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Genetics
Subjects:
FMR1 gene
CGG repeats
AGG interspersion pattern
modeling allelic complexity
allelic score
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.557147/full

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https://www.frontiersin.org/articles/10.3389/fgene.2020.557147/full

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