FoxO3 increases miR-34a to cause palmitate-induced cholangiocyte lipoapoptosis

FoxO3 increases miR-34a to cause palmitate-induced cholangiocyte lipoapoptosis

Nonalcoholic steatohepatitis (NASH) patients have elevated plasma saturated free fatty acid levels. These toxic fatty acids can induce liver cell death and our recent results demonstrated that the biliary epithelium may be susceptible to lipotoxicity. Here, we explored the molecular mechanisms of ch...

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Bibliographic Details
Main Authors: Sathish Kumar Natarajan, Bailey A. Stringham, Ashley M. Mohr, Cody J. Wehrkamp, Sizhao Lu, Mary Anne Phillippi, Dee Harrison-Findik, Justin L. Mott
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Journal of Lipid Research
Subjects:
nonalcoholic fatty liver disease
steatohepatitis
microRNA-34a
forkhead box transcription factor class O3
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520338220

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http://www.sciencedirect.com/science/article/pii/S0022227520338220

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