High-content screen in human pluripotent cells identifies miRNA-regulated pathways controlling pluripotency and differentiation

High-content screen in human pluripotent cells identifies miRNA-regulated pathways controlling pluripotency and differentiation

Abstract Background By post-transcriptionally regulating multiple target transcripts, microRNAs (miRNAs or miR) play important biological functions. H1 embryonic stem cells (hESCs) and NTera-2 embryonal carcinoma cells (ECCs) are two of the most widely used human pluripotent model cell lines, sharin...

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Bibliographic Details
Main Authors: Ildercílio Mota de Souza Lima, Josiane Lilian dos Santos Schiavinato, Sarah Blima Paulino Leite, Danuta Sastre, Hudson Lenormando de Oliveira Bezerra, Bruno Sangiorgi, Amanda Cristina Corveloni, Carolina Hassibe Thomé, Vitor Marcel Faça, Dimas Tadeu Covas, Marco Antônio Zago, Mauro Giacca, Miguel Mano, Rodrigo Alexandre Panepucci
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Stem Cell Research & Therapy
Subjects:
Human embryonic stem cells
Pluripotent stem cells
MicroRNA
Cell differentiation
Receptors, Notch
Microscopy, fluorescence
Online Access:http://link.springer.com/article/10.1186/s13287-019-1318-6

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http://link.springer.com/article/10.1186/s13287-019-1318-6

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