In silico Identification of Key Factors Driving the Response of Muscle Sensory Neurons to Noxious Stimuli

In silico Identification of Key Factors Driving the Response of Muscle Sensory Neurons to Noxious Stimuli

Nociceptive nerve endings embedded in muscle tissue transduce peripheral noxious stimuli into an electrical signal [i.e., an action potential (AP)] to initiate pain sensations. A major contributor to nociception from the muscles is mechanosensation. However, due to the heterogeneity in the expressio...

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Bibliographic Details
Main Authors: Sridevi Nagaraja, Luis F. Queme, Megan C. Hofmann, Shivendra G. Tewari, Michael P. Jankowski, Jaques Reifman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neuroscience
Subjects:
musculoskeletal pain
nociceptor
ion channels
computational analysis
action potential
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.719735/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.719735/full

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