Extracellular superoxide dismutase protects Histoplasma yeast cells from host-derived oxidative stress.

In order to establish infections within the mammalian host, pathogens must protect themselves against toxic reactive oxygen species produced by phagocytes of the immune system. The fungal pathogen Histoplasma capsulatum infects both neutrophils and macrophages but the mechanisms enabling Histoplasma...

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Bibliographic Details
Main Authors: Brian H Youseff, Eric D Holbrook, Katherine A Smolnycki, Chad A Rappleye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3355102?pdf=render