Gene-Edited Interleukin CAR-T Cells Therapy in the Treatment of Malignancies: Present and Future

In recent years, chimeric antigen receptor T cells (CAR-T cells) have been faced with the problems of weak proliferation and poor persistence in the treatment of some malignancies. Researchers have been trying to perfect the function of CAR-T by genetically modifying its structure. In addition to th...

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Bibliographic Details
Main Authors: Zhengchao Zhang, Lele Miao, Zhijian Ren, Futian Tang, Yumin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
TME
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.718686/full