Notch1 Activation Up-Regulates Pancreatic and Duodenal Homeobox-1

Notch1 Activation Up-Regulates Pancreatic and Duodenal Homeobox-1

Transcription factor pancreatic and duodenal homeobox-1 (PDX-1) plays an essential role in pancreatic development, β-cell differentiation, maintenance of normal β-cell function and tumorigenesis. PDX-1 expression is tightly controlled through a variety of mechanisms under different cellular contexts...

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Bibliographic Details
Main Authors: Min Li, F. Charles Brunicardi, William E. Fisher, David Dawson, Neil Senzer, James Wu, John Nemunaitis, Shi-He Liu, Guisheng Zhou, Juehua Yu
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Genes
Subjects:
Notch1
NICD
PDX-1
insulin
hyperinsulinemia
hypoglycemia
Online Access:http://www.mdpi.com/2073-4425/4/3/358

Internet

http://www.mdpi.com/2073-4425/4/3/358

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