Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

Physical exercise promotes brain angiogenesis through an unknown signalling cascade. Morlandet al. identify the elusive muscle-brain communication and show that lactate produced by muscle activity binds to its receptor HCAR1 in brain vessel-surrounding cells, stimulating VEGF production and brain an...

Full description

Bibliographic Details
Main Authors: Cecilie Morland, Krister A. Andersson, Øyvind P. Haugen, Alena Hadzic, Liv Kleppa, Andreas Gille, Johanne E. Rinholm, Vuk Palibrk, Elisabeth H. Diget, Lauritz H. Kennedy, Tomas Stølen, Eivind Hennestad, Olve Moldestad, Yiqing Cai, Maja Puchades, Stefan Offermanns, Koen Vervaeke, Magnar Bjørås, Ulrik Wisløff, Jon Storm-Mathisen, Linda H. Bergersen
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15557

Internet

https://doi.org/10.1038/ncomms15557

Similar Items