A functional polymorphism in the prodynorphin gene affects cognitive flexibility and brain activation during reversal learning.

A functional polymorphism in the prodynorphin gene affects cognitive flexibility and brain activation during reversal learning.

Whether the opioid system plays a role in the ability to flexibly adapt behavior is still unclear. We used fMRI to investigate the effect of a nucleotide tandem repeat (68-bp VNTR) functional polymorphism of the prodynorphin gene on cerebral activation during a reversal learning task in which partic...

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Bibliographic Details
Main Authors: Mikhail eVotinov, Jürgen ePripfl, Christian eWindischberger, Ewald eMoser, Uta eSailer, Claus eLamm
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Genetics
Reversal Learning
functional MRI
Prodynorphin
Opioid system
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00172/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00172/full

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