Neferine Attenuates the Protein Level and Toxicity of Mutant Huntingtin in PC-12 Cells via Induction of Autophagy

Neferine Attenuates the Protein Level and Toxicity of Mutant Huntingtin in PC-12 Cells via Induction of Autophagy

Mutant huntingtin aggregation is highly associated with the pathogenesis of Huntington’s disease, an adult-onset autosomal dominant disorder, which leads to a loss of motor control and decline in cognitive function. Recent literature has revealed the protective role of autophagy in neurodegenerative...

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Bibliographic Details
Main Authors: Vincent Kam Wai Wong, An Guo Wu, Jing Rong Wang, Liang Liu, Betty Yuen-Kwan Law
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:Molecules
Subjects:
autophagy
Nelumbo nucifera
neferine
AMPK
mTOR
a-synuclein
huntingtin
PC-12
bioactivity
natural products
mechanism of action
Online Access:http://www.mdpi.com/1420-3049/20/3/3496

Internet

http://www.mdpi.com/1420-3049/20/3/3496

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