Unique Roles for Streptococcus pneumoniae Phosphodiesterase 2 in Cyclic di-AMP Catabolism and Macrophage Responses

Unique Roles for Streptococcus pneumoniae Phosphodiesterase 2 in Cyclic di-AMP Catabolism and Macrophage Responses

Cyclic di-AMP (c-di-AMP) is an important signaling molecule for pneumococci, and as a uniquely prokaryotic product it can be recognized by mammalian cells as a danger signal that triggers innate immunity. Roles of c-di-AMP in directing host responses during pneumococcal infection are only beginning...

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Bibliographic Details
Main Authors: Alicia K. Wooten, Anukul T. Shenoy, Emad I. Arafa, Hisashi Akiyama, Ian M. C. Martin, Matthew R. Jones, Lee J. Quinton, Suryaram Gummuluru, Guangchun Bai, Joseph P. Mizgerd
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
cyclic di-AMP
innate immunity
interferon-β
macrophages
pneumococcus
pneumonia
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00554/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00554/full

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