Searching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells

Searching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells

Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation. Indomethacin, a non-steroidal anti-inflammatory drug,...

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Bibliographic Details
Main Authors: Freddy López-Contreras, Matías Muñoz-Uribe, Jorge Pérez-Laines, Laura Ascencio-Leal, Andrés Rivera-Dictter, Antonia Martin-Martin, Rafael A. Burgos, Pablo Alarcon, Rodrigo López-Muñoz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
indomethacin
spermidine/spermine-N1-acetyltransferase
polyamine
non-small cell lung cancer
metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01670/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01670/full

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