Intrinsic Resistance to EGFR-Tyrosine Kinase Inhibitors in <i>EGFR</i>-Mutant Non-Small Cell Lung Cancer: Differences and Similarities with Acquired Resistance

Intrinsic Resistance to EGFR-Tyrosine Kinase Inhibitors in <i>EGFR</i>-Mutant Non-Small Cell Lung Cancer: Differences and Similarities with Acquired Resistance

Activating mutations in the <i>epidermal growth factor</i> <i>receptor</i> gene occur as early cancer-driving clonal events in a subset of patients with non-small cell lung cancer (NSCLC) and result in increased sensitivity to EGFR-tyrosine-kinase-inhibitors (EGFR-TKIs). Desp...

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Bibliographic Details
Main Authors: Eric Santoni-Rugiu, Linea C. Melchior, Edyta M. Urbanska, Jan N. Jakobsen, Karin de Stricker, Morten Grauslund, Jens B. Sørensen
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
EGFR-mutated non-small cell lung cancer
EGFR-TKI
intrinsic resistance
resistance mechanisms
Online Access:https://www.mdpi.com/2072-6694/11/7/923

Internet

https://www.mdpi.com/2072-6694/11/7/923

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