Non-Lynch Familial and Early-Onset Colorectal Cancer Explained by Accumulation of Low-Risk Genetic Variants

Non-Lynch Familial and Early-Onset Colorectal Cancer Explained by Accumulation of Low-Risk Genetic Variants

A large proportion of familial and/or early-onset cancer patients do not carry pathogenic variants in known cancer predisposing genes. We aimed to assess the contribution of previously validated low-risk colorectal cancer (CRC) alleles to familial/early-onset CRC (fCRC) and to serrated polyposis. We...

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Bibliographic Details
Main Authors: Pilar Mur, Nuria Bonifaci, Anna Díez-Villanueva, Elisabet Munté, Maria Henar Alonso, Mireia Obón-Santacana, Gemma Aiza, Matilde Navarro, Virginia Piñol, Joan Brunet, Ian Tomlinson, Gabriel Capellá, Victor Moreno, Laura Valle
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
hereditary colorectal cancer
cancer predisposition
serrated polyposis
polygenic risk score
Online Access:https://www.mdpi.com/2072-6694/13/15/3857

Internet

https://www.mdpi.com/2072-6694/13/15/3857

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