Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4–CD8–double negative (DN) thymocytes to generate αβ T cells in the thymus. However, how these signals ensure a high-fidelity proteome and safeguard the clonal diversification of the pre-selection TCR repertoire gi...

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Bibliographic Details
Main Authors: Xia Liu, Jingjing Yu, Longyong Xu, Katharine Umphred-Wilson, Fanglue Peng, Yao Ding, Brendan M Barton, Xiangdong Lv, Michael Y Zhao, Shengyi Sun, Yuning Hong, Ling Qi, Stanley Adoro, Xi Chen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
thymocytes
proteostasis
beta-selection
ER-associated degradation
ER stress
Online Access:https://elifesciences.org/articles/69975

Internet

https://elifesciences.org/articles/69975

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