Increased Specific Labeling of INS-1 Pancreatic Beta-Cell by Using RIP-Driven Cre Mutants with Reduced Activity.

Increased Specific Labeling of INS-1 Pancreatic Beta-Cell by Using RIP-Driven Cre Mutants with Reduced Activity.

Ectopically expressed Cre recombinase in extrapancreatic tissues in RIP-Cre mice has been well documented. The objective of this study was to find a simple solution that allows for improved beta-cell specific targeting. To this end, the RIP-Cre and reporter CMV-loxP-DsRed-loxP-EGFP expression casset...

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Bibliographic Details
Main Authors: Gen-cheng Gong, Wen-zhu Fan, Di-zheng Li, Xiong Tian, Shao-jun Chen, Yu-cai Fu, Wen-can Xu, Chi-ju Wei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0129092

Internet

https://doi.org/10.1371/journal.pone.0129092

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