Cytoplasmic gelsolin increases mitochondrial activity and reduces Aβ burden in a mouse model of Alzheimer's disease

Cytoplasmic gelsolin increases mitochondrial activity and reduces Aβ burden in a mouse model of Alzheimer's disease

Accumulation of amyloid-β (Aβ) peptides is thought to be a critical event in the pathology of Alzheimer's disease (AD), because they induce multiple neurotoxic effects, including mitochondrial dysfunction and apoptotic cell death. Therefore the reduction of Aβ is considered a primary therapeuti...

Full description

Bibliographic Details
Main Authors: Desiree Antequera, Teo Vargas, Cristina Ugalde, Carlos Spuch, Jose Antonio Molina, Isidro Ferrer, Felix Bermejo-Pareja, Eva Carro
Format: Article
Language:English
Published: Elsevier 2009-10-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Gelsolin
Lentiviral vectors
Choroid plexus
Mitochondrial dysfunction
Nitric oxide
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109001624

Internet

http://www.sciencedirect.com/science/article/pii/S0969996109001624

Similar Items