TRPM4 and TRPM5 Channels Share Crucial Amino Acid Residues for Ca<sup>2+</sup> Sensitivity but Not Significance of PI(4,5)P<sub>2</sub>

TRPM4 and TRPM5 Channels Share Crucial Amino Acid Residues for Ca<sup>2+</sup> Sensitivity but Not Significance of PI(4,5)P<sub>2</sub>

Transient receptor potential melastatin member 4 (TRPM4) and 5 (TRPM5) channels are Ca<sup>2+</sup>-activated nonselective cation channels. Intracellular Ca<sup>2+</sup> is the most important regulator for them to open, though PI(4,5)P<sub>2</sub>, a membrane phos...

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Bibliographic Details
Main Authors: Soichiro Yamaguchi, Akira Tanimoto, Shinsuke Iwasa, Ken-ichi Otsuguro
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
TRPM4
TRPM5
Ca<sup>2+</sup>-binding site
PI(4,5)P<sub>2</sub>
patch clamp
site-directed mutagenesis
Online Access:https://www.mdpi.com/1422-0067/20/8/2012

Internet

https://www.mdpi.com/1422-0067/20/8/2012

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