Sodium Acetate Inhibit TGF-β1-Induced Activation of Hepatic Stellate Cells by Restoring AMPK or c-Jun Signaling

Sodium Acetate Inhibit TGF-β1-Induced Activation of Hepatic Stellate Cells by Restoring AMPK or c-Jun Signaling

Short-chain fatty acids (SCFAs) are crucial gut microbial metabolites that play a major role in the occurrence and development of hepatic fibrosis (HF). However, the effect of SCFAs on hepatic stellate cells (HSCs), the major pro-fibrogenic cells, is yet undefined. In this study, the effects of thre...

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Bibliographic Details
Main Authors: Weiwei Li, Mingjuan Deng, Jiahui Gong, Xiaoying Zhang, Shaoyang Ge, Liang Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Nutrition
Subjects:
short chain fatty acid
fibrosis
hepatic stellate cells
AMPK
PPARγ
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2021.729583/full

Internet

https://www.frontiersin.org/articles/10.3389/fnut.2021.729583/full

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