Macrophage expression of E3 ubiquitin ligase Grail protects mice from lipopolysaccharide-induced hyperinflammation and organ injury.

Macrophage expression of E3 ubiquitin ligase Grail protects mice from lipopolysaccharide-induced hyperinflammation and organ injury.

Multiple organ dysfunction caused by hyperinflammation remains the major cause of mortality during sepsis. Excessive M1-macrophage activation leads to systemic inflammatory responses. Gene related to anergy in lymphocytes (Grail) is regarded as an important regulator of T cells that functions by dim...

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Bibliographic Details
Main Authors: Chih-Chin Shih, Pei-Yao Liu, Jye-Hann Chen, Mei-Hui Liao, Chih-Ming Hsieh, Shuk-Man Ka, Chin-Chen Wu, Hui-Tsu Lin, Ti-Hui Wu, Ying-Chuan Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0208279

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https://doi.org/10.1371/journal.pone.0208279

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