Analytical and Sample Preparation Protocol for Therapeutic Drug Monitoring of 12 Thiopurine Metabolites Related to Clinical Treatment of Inflammatory Bowel Disease

Analytical and Sample Preparation Protocol for Therapeutic Drug Monitoring of 12 Thiopurine Metabolites Related to Clinical Treatment of Inflammatory Bowel Disease

Thiopurines (TP) represent an important therapeutic tool for the treatment of inflammatory bowel diseases (IBD) in the current situation of rising incidence and health care costs. The results of multiple clinical studies aimed at finding correlations between levels of TP metabolites and response of...

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Bibliographic Details
Main Authors:	Daniel Pecher, Svetlana Dokupilová, Zuzana Zelinková, Maikel Peppelenbosch, Jana Lučeničová, Veronika Mikušová, Peter Mikuš
Format:	Article
Language:	English
Published:	MDPI AG 2018-07-01
Series:	Molecules
Subjects:	inflammatory bowel diseases therapeutic drug monitoring profiling of thiopurines comprehensive stability study sample treatment clinical analysis high performance liquid chromatography mass spectrometry
Online Access:	http://www.mdpi.com/1420-3049/23/7/1744

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